Fungicides Organic Intermediate 4-Chlorobenzaldehyde CAS 104-88-1 Insecticides

Fungicides Organic Intermediate 4-Chlorobenzaldehyde CAS 104-88-1 Insecticides

Introduction:

p-Chlorobenzaldehyde is also known as 4-chlorobenzaldehyde. Colorless flaky crystals to light yellow powder. Molecular weight 140.57. Melting point 47.5℃. Boiling point 213～214℃. Relative density 1.196 (61/4℃). Refractive index 1.5552 (61℃). Flash point 87℃. Insoluble in water, easily soluble in ethanol, benzene, soluble in water. Can evaporate with water vapor. Used as medicine and dye intermediate, used in the manufacture of fenalol, aminophenylaminobutyric acid, etc. Obtained by chlorination and hydrolysis of p-chlorotoluene. It can also be obtained by oxidation of p-chlorotoluene with manganese dioxide. It can also be obtained by oxidation of p-chlorotoluene with air. Preparation of plant growth regulator paclobutrazol: p-chlorobenzaldehyde and 2,2-dimethyl-3-butanone are used as raw materials, reacted in sodium hydroxide and tert-butanol solution to generate 1-(2,2-dimethyl-3-keto-4-pentene) p-chlorobenzene, hydrogenated at high temperature in ethyl acetate solution with nickel as catalyst to generate 1-(2,2-dimethyl-3-pentanone) p-chlorobenzene, added bromine in carbon tetrachloride solution to generate 1-(2,2-dimethyl-4-bromo-3-pentanone) p-chlorobenzene, further reacted with 1,2,4-triazole in acetoe solution, and finally generated paclobutrazol in methanol solution of sodium borohydride. Baclofen is used as a skeletal muscle relaxant and antispasmodic agent for the spine. p-Chlorobenzyl-bis-ethylacetoacetate is generated by condensation of p-chlorobenzaldehyde and ethyl acetoacetate. Heating and hydrolyzing to obtain p-chlorophenyl glutaric acid. Dehydration and cyclization with acetic anhydride to generate p-chlorophenyl glutaric anhydride. It is then aminated with concentrated ammonia to generate p-chlorophenylglutaric acid imide, which is then ring-opened and degraded to obtain the product.

Uses:

p-Chlorobenzaldehyde is an intermediate of the fungicide tebuconazole, the plant growth regulator chlorfenapyr, and the insecticide chlorfenapyr. It is used as an intermediate of fenalool and phenylamino acid in medicine, and is also an intermediate of dyes. It is used to manufacture sedatives such as fenalool and dye acid brilliant blue 6B.