Anhydrous Valerophenone CAS 1009-14-9 Low Moisture 0.05% Water Synthesis Liquid

A Grignard addition to a ketone consumes one equivalent of reagent for every equivalent of water present, and the magnesium hydroxide that forms clouds the reaction and slows the work up. When valerophenone (CAS 1009-14-9) is used as the electrophile in an organometallic step, its water content rather than its assay becomes the process critical parameter.

This anhydrous grade is dried by azeotropic distillation with a high purity hydrocarbon entrainer, filtered, and filled under argon with a molecular sieve in the drum headspace. Water is specified at 0.05 percent maximum and verified by Karl Fischer titration on every lot, while the acid value is held at 0.02 so the ketone does not consume base before the reaction begins.

• Water 0.05% maximum by Karl Fischer: no reagent loss in Grignard, organolithium and other moisture sensitive steps
• Argon blanket with headspace sieve: moisture does not creep back during transport or partial use
• Acid value 0.02 maximum: no premature consumption of base or catalyst in the charge
• Azeotropic drying, no chemical drier: no drying agent residues or salts left behind in the product
• Low colour 10 APHA: no colour contribution to the final product after the reaction
• Sampling port on the drum: dryness can be verified on arrival without opening the drum to atmosphere

Used in organometallic and moisture sensitive synthesis, in Grignard routes to tertiary alcohols and substituted amines, and in flow chemistry where a dry ketone feed is required for reproducible residence time behaviour.

Transfer under argon using a closed cannula or a pump rather than an open pour, and replace the headspace sieve if the drum is held for more than six months after opening. Our technical note gives an incoming inspection Karl Fischer procedure and expected moisture pick up in an open container.

Supplied in 1 kg amber glass bottles purged with argon, 5 kg lined cans and 25 kg iron drums with phenolic epoxy lining and a headspace sieve cartridge. Labels record lot number, assay, water at release and the storage instruction.

Store between 5 and 25 degrees C under argon, away from moisture and light. Delivery takes 7 to 15 working days; independent verification of water content before shipment can be arranged on request.

Each lot is released with a Certificate of Analysis reporting assay, water by Karl Fischer, acid value, aldehyde content, colour and density, with the GC chromatogram attached. A 200 g retention sample is sealed under argon for 18 months.

We provide a GHS safety data sheet, an incoming inspection note including the Karl Fischer method, and an argon transfer handling instruction. Trace water verification by an independent laboratory is available at the buyer's cost.