Anhydrous HFIP CAS 920-66-1 50 ppm Water Moisture Sensitive Reaction Solvent

Water in HFIP is not a neutral bystander. It forms a strongly acidic mixture with the solvent, and at 0.1% it is enough to hydrolyse an acid chloride, kill an organometallic or etch a metal surface. Getting below 100 ppm takes a drying step and packaging that keeps it there, which is why most suppliers quote 0.1% and stop.

We dry over activated molecular sieve under argon and fill through a closed transfer line, so the Karl Fischer result on the certificate is measured after packaging rather than before. Septum caps on the 1 kg bottles let a customer take material by syringe without opening the bottle to humid air.

If your reaction is sensitive at the 100 ppm level, this is the grade to use, and the price difference over the standard material is small compared with a failed batch.

• Water 50 ppm maximum after packaging: safe for acid chlorides, organometallics and moisture sensitive catalysts
• Septum caps on 1 kg bottles: syringe transfer without opening to air
• Molecular sieve dried under argon: no drying agent residue or fines carried into the product
• Free fluoride 5 ppm maximum: no acid catalysed side reactions from the solvent itself
• Karl Fischer measured after filling: the number on the COA reflects the bottle you receive
• Nitrogen blanketed drums: dryness survives a sea freight cycle

Acid chloride and anhydride chemistry, organometallic reactions where the solvent must not protonate the reagent, and any step where HFIP is chosen precisely because it is a non nucleophilic polar medium.

Transfer by syringe or cannula through the septum and keep the bottle under argon between uses. Do not dry it further over sieve in the lab unless the sieve has been activated, since wet sieve will add water rather than remove it.

1 kg septum bottle, 5 kg can and 25 kg drum, all argon filled and closed transfer filled. Labels record the water content measured after packaging.

Store under argon between 15 and 25 degrees C, sealed, away from bases. Air freight for bottles; drums by sea.

COA with assay, water by Karl Fischer measured after filling, free fluoride, residue and colour, plus the GC trace. A retention sample is kept under argon for 18 months.

We can supply a small argon cylinder with the first order so the customer can re-blanket after each use, and a note on septum life for repeated sampling.